top of page

CvergenX is at the forefront of radiation oncology innovation, providing the biological intelligence layer that makes biology driven radiation a reality

Transforming Radiaton Oncology Through Biological Intelligence

Next-Gen Oncology

TECHNOLOGY

Predictive Analytics for Biologically Guided Radiotherapy

CvergenX’s precisionRT Dose (pRTD™) platform is built on three proprietary, clinically validated components:

 

• RSI (Radiosensitivity Index): A gene-expression biomarker that quantifies intrinsic tumor radiosensitivity.

• GARD (Genomic Adjusted Radiation Dose): A novel metric that integrates RSI with delivered RT dose to quantify biological effect and    predict clinical outcomes.

• popGARD / RxRSI: Population- and patient-specific tools that evaluate and optimize radiation dose to maximize tumor control while      accounting for normal tissue toxicity.

CvergenX’s technology is among the most extensively validated platforms in radiation oncology:

• International validation across 27 studies and multiple institutions

• Prospective validation completed in a Phase II soft tissue sarcoma trial (HEAT), confirming GARD-      based dose predictions

• Ongoing Phase II trial in triple-negative breast cancer; additional trials planned in HPV-associated    oropharyngeal cancer

• RSI/GARD operational in a CLIA-certified laboratory at Moffitt Cancer Center

• Strong intellectual property estate with issued U.S. and international patents

Meet The Team

Leadership Team: Deep Scientific & Clinical Expertise

Javier.png

Javier Torres-Roca, MD

CEO

Dr. Javier F. Torres-Roca is a physician-scientist and entrepreneur recognized internationally for his work at the intersection of radiation oncology, genomics, and mathematical modeling. He is a Senior Member at Moffitt Cancer Center and Professor of Oncologic Sciences at the University of South Florida, where his research has helped define the field of precision radiation oncology.

Dr. Torres-Roca is the inventor and co-developer of the Radiosensitivity Index (RSI) and the Genomic Adjusted Radiation Dose (GARD) framework, foundational innovations that integrate tumor genomics with radiation dose optimization. These concepts underpin a new paradigm for biologically personalized radiation therapy and have been validated across multiple cancer types.

He is a co-founder of Cvergenx, where he leads the scientific vision behind the company’s Precision Genomic Radiation Therapy (pGRT™) platform. Dr. Torres-Roca is the inventor on multiple issued and pending patents supporting RSI, GARD, and RxRSI, translating academic discoveries into scalable clinical decision-support technologies.

His career reflects a commitment to bridging academic innovation and commercial execution to improve cancer treatment through data-driven, patient-specific approaches.

  • LinkedIn
Jake.jpg

Jacob G. Scott, MD, D.Phil

CSO

Dr. Jacob G. Scott is a physician-scientist and entrepreneur whose interdisciplinary work bridges radiation oncology, genomics, mathematics, and evolutionary modeling. He is a Professor and staff physician at the Cleveland Clinic in the Department of Translational Hematology & Oncology Research and Radiation Oncology, with academic affiliations spanning physics, data science, and medicine. 

Dr. Scott’s research focuses on understanding and overcoming treatment resistance through quantitative and evolutionary approaches, applying mathematical modeling to cancer therapy and integrating tumor biology with clinical outcomes. He is a co-inventor of the Genomic Adjusted Radiation Dose (GARD) framework—a genomics-driven method to personalize radiation dosing that represents a major advance in precision radiation oncology. 

In addition to his academic roles, Dr. Scott brings industry experience through consulting, advisory engagements, and equity interests in biotechnology and medical technology ventures, including Cvergenx and other innovative companies. At Cvergenx, he serves as Chief Scientific Officer, helping guide the scientific strategy that commercializes genomic and mathematical innovations for precision radiation therapy. 

Dr. Scott’s career reflects a commitment to translating foundational science into commercially viable technologies that empower clinicians and improve patient care through data-driven, individualized treatment paradigms.

  • Facebook
  • Twitter
  • LinkedIn
Steven.png

Steven A. Eschrich, PHD

CTO

Dr. Steven A. Eschrich is a computational biologist, entrepreneur, and co-founder of Cvergenx, where he serves as Chief Technology Officer. He is a Senior Member in the Department of Biostatistics and Bioinformatics at the H. Lee Moffitt Cancer Center & Research Institute and Associate Professor of Oncologic Sciences at the University of South Florida. In these roles, he leads the development of scalable machine-learning and bioinformatics platforms that translate complex genomic data into actionable insights for personalized cancer care. 

Dr. Eschrich’s research focuses on genomic biomarker discovery, systems biology, and computational modeling to quantify tumor radiosensitivity and predict treatment response. He is a co-inventor of the Radiation Sensitivity Index (RSI)—a gene expression–based model of intrinsic tumor radiosensitivity—and his work underpins the genomic frameworks now moving radiation therapy toward patient-specific optimization. 

As CTO of Cvergenx, Dr. Eschrich drives the company’s technology strategy, advancing the Precision Genomic Radiation Therapy (pGRT™) platform that integrates patented genomic and mathematical models into clinical decision support tools for radiation oncology. His leadership bridges cutting-edge computational science with translational impact, enabling data-driven personalization of radiation treatment. 

  • Facebook
  • Twitter
  • LinkedIn

LATEST INSIGHTS

Selected Publications

 (for a full bibliography please contact us)

1. Systems biology modeling of the radiation sensitivity network: a biomarker discovery platform. Int J RadiatOncol Biol Phys. 2009 Oct 1;75(2):497-505. doi.org/10.1016/j.ijrobp.2009.05.056. PMID: 19735874

2. A gene expression model of intrinsic tumor radiosensitivity: prediction of response and prognosis afterchemoradiation. Int J Radiat Oncol Biol Phys. 2009 Oct 1;75(2):489-96. doi:10.1016/j.ijrobp.2009.06.014.PMID: 19735873.

3. Validation of a Radiosensitivity Molecular Signature in Breast Cancer. Clin Cancer Res. 2012 Sep 15;18(18):5134-43. doi: 10.1158/1078- 0432.CCR-12-0891. Epub 2012 Jul 25. PMID: 22832933

4. Radiosensitivity Index Predicts for Survival with Adjuvant Radiation in Resectable Pancreatic Cancer. RadiotherOncol. 2015 Oct;117(1):159-64. doi: 10.1016/j.radonc.2015.07.018. Epub 2015 Jul 30. PMID: 26235848.

5. The Radiosensitivity Index Predicts for Overall Survival in Glioblastoma. Oncotarget. 2015 Oct 27;6(33):34414-22. doi: 10.18632/oncotarget.5437. PMID: 26451615.

6. Integration of a Radiosensitivity Molecular Signature into the Assessment of Local Recurrence Risk in BreastCancer. Int J Radiat Oncol Biol Phys. 2015 Nov 1;93(3):631-8. doi: 10.1016/j.ijrobp.2015.06.021. Epub 2015 Jun 25. PMID: 26461005. 

7. A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study. Lancet Oncol. 2017 Feb;18(2):202-211. doi: 10.1016/S1470-2045(16)30648-9. Epub 2016 Dec 18. PMID: 27993569.

8. Identification and validation of single-sample breast cancer radiosensitivity gene expression predictors. Breast Cancer Res 2018; 20(1): 64.

9. Utilizing the genomically adjusted radiation dose (GARD) to personalize adjuvant radiotherapy in triplenegative breast cancer management. EBioMedicine. 2019 Sep;47:163-169. doi: 10.1016/j.ebiom.2019.08.019.PMID: 31416721.

10. Personalizing Radiotherapy Prescription Dose Using Genomic Markers of Radiosensitivity and Normal Tissue Toxicity in NSCLC. J Thorac Oncol. 2021 Mar; 16(3):428-438. doi: 10.1016/j.jtho.2020.11.008.

11. Pan-cancer prediction of radiotherapy benefit using genomic-adjusted radiation dose (GARD): a cohort-based pooled analysis. Lancet Oncol. 2021 Sep;22(9):1221- 1229. doi: 10.1016/S1470-2045(21)00347-8. Epub 2021 Aug 4. PMID: 34363761.

12.     Radiosensitivity is associated with antitumor immunity in estrogen receptor-negative breast cancer. Breast Cancer Res Treat 2023; 197(3): 479–88.

13.  Validation of a genome-based model for adjusting radiotherapy dose (GARD) in patients with locally advanced rectal cancer. Sci Rep 2024; 14(1): 21572.

14. Personalized treatment in HPV+ oropharynx cancer using genomic adjusted radiation dose. The Journal of Clinical Investigation 2025; 135(19) e194073. https://doi.org/10.1172/JCI194073

bottom of page