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CvergenX is at the forefront of radiation oncology innovation, providing the biological intelligence layer that makes biology driven radiation a reality

Transforming Radiaton Oncology Through Biological Intelligence

Next-Gen Oncology

TECHNOLOGY

Predictive Analytics for Biologically Guided Radiotherapy

CvergenX’s precisionRT Dose (pRTD™) platform is built on three proprietary, clinically validated components:

 

• RSI (Radiosensitivity Index): A gene-expression biomarker that quantifies intrinsic tumor radiosensitivity.

• GARD (Genomic Adjusted Radiation Dose): A novel metric that integrates RSI with delivered RT dose to quantify biological effect and    predict clinical outcomes.

• popGARD / RxRSI: Population- and patient-specific tools that evaluate and optimize radiation dose to maximize tumor control while      accounting for normal tissue toxicity.

CvergenX’s technology is among the most extensively validated platforms in radiation oncology:

• International validation across 27 studies and multiple institutions

• Prospective validation completed in a Phase II soft tissue sarcoma trial (HEAT), confirming GARD-      based dose predictions

• Ongoing Phase II trial in triple-negative breast cancer; additional trials planned in HPV-associated    oropharyngeal cancer

• RSI/GARD operational in a CLIA-certified laboratory at Moffitt Cancer Center

• Strong intellectual property estate with issued U.S. and international patents

Meet The Team

Leadership Team: Deep Scientific & Clinical Expertise

LATEST INSIGHTS

Selected Publications

 (for a full bibliography please contact us)

1. Systems biology modeling of the radiation sensitivity network: a biomarker discovery platform. Int J RadiatOncol Biol Phys. 2009 Oct 1;75(2):497-505. doi.org/10.1016/j.ijrobp.2009.05.056. PMID: 19735874

2. A gene expression model of intrinsic tumor radiosensitivity: prediction of response and prognosis afterchemoradiation. Int J Radiat Oncol Biol Phys. 2009 Oct 1;75(2):489-96. doi:10.1016/j.ijrobp.2009.06.014.PMID: 19735873.

3. Validation of a Radiosensitivity Molecular Signature in Breast Cancer. Clin Cancer Res. 2012 Sep 15;18(18):5134-43. doi: 10.1158/1078- 0432.CCR-12-0891. Epub 2012 Jul 25. PMID: 22832933

4. Radiosensitivity Index Predicts for Survival with Adjuvant Radiation in Resectable Pancreatic Cancer. RadiotherOncol. 2015 Oct;117(1):159-64. doi: 10.1016/j.radonc.2015.07.018. Epub 2015 Jul 30. PMID: 26235848.

5. The Radiosensitivity Index Predicts for Overall Survival in Glioblastoma. Oncotarget. 2015 Oct 27;6(33):34414-22. doi: 10.18632/oncotarget.5437. PMID: 26451615.

6. Integration of a Radiosensitivity Molecular Signature into the Assessment of Local Recurrence Risk in BreastCancer. Int J Radiat Oncol Biol Phys. 2015 Nov 1;93(3):631-8. doi: 10.1016/j.ijrobp.2015.06.021. Epub 2015 Jun 25. PMID: 26461005. 

7. A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study. Lancet Oncol. 2017 Feb;18(2):202-211. doi: 10.1016/S1470-2045(16)30648-9. Epub 2016 Dec 18. PMID: 27993569.

8. Identification and validation of single-sample breast cancer radiosensitivity gene expression predictors. Breast Cancer Res 2018; 20(1): 64.

9. Utilizing the genomically adjusted radiation dose (GARD) to personalize adjuvant radiotherapy in triplenegative breast cancer management. EBioMedicine. 2019 Sep;47:163-169. doi: 10.1016/j.ebiom.2019.08.019.PMID: 31416721.

10. Personalizing Radiotherapy Prescription Dose Using Genomic Markers of Radiosensitivity and Normal Tissue Toxicity in NSCLC. J Thorac Oncol. 2021 Mar; 16(3):428-438. doi: 10.1016/j.jtho.2020.11.008.

11. Pan-cancer prediction of radiotherapy benefit using genomic-adjusted radiation dose (GARD): a cohort-based pooled analysis. Lancet Oncol. 2021 Sep;22(9):1221- 1229. doi: 10.1016/S1470-2045(21)00347-8. Epub 2021 Aug 4. PMID: 34363761.

12.     Radiosensitivity is associated with antitumor immunity in estrogen receptor-negative breast cancer. Breast Cancer Res Treat 2023; 197(3): 479–88.

13.  Validation of a genome-based model for adjusting radiotherapy dose (GARD) in patients with locally advanced rectal cancer. Sci Rep 2024; 14(1): 21572.

14. Personalized treatment in HPV+ oropharynx cancer using genomic adjusted radiation dose. The Journal of Clinical Investigation 2025; 135(19) e194073. https://doi.org/10.1172/JCI194073

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